Michael Calore: Is there a distinction between how a lot weight males lose on these medicine and ladies lose on them?
Emily Mullin: Yeah. So I am glad you pointed that out, as a result of that does appear to be one of many indicators that folks reply in a different way to those medicine. And what among the scientific trials are exhibiting is that girls, for no matter motive, appear to lose extra weight than males on these medicine. So one attainable motive is that girls simply have a special fats composition than males. One more reason is that girls, on common, are smaller than males, and so if you’re taking the identical quantity of a drug, and it has much less locations to go within the physique, it is possibly more practical than anyone who is greater and has extra weight on them.
Michael Calore: I see. So you may’t simply take the drug and lose a bunch of weight with out additionally making another life-style adjustments, proper?
Emily Mullin: Yeah, precisely. So in scientific trials of semaglutide and tirzepatide, simply in order that listeners are conscious, semaglutide, we’re speaking about Ozempic and WeGovy, and tirzepatide, speaking about Mounjaro and ZepBound, these model names. So in scientific trials, in fact, these are very rigorously designed, and persons are taking these medicine alongside a really prescribed weight loss program and train plan. So these are the perfect situations of taking this drug. And naturally, in actual life folks won’t be following that fairly as properly. And one other factor is, one of many consultants I talked to, an endocrinologist, she very astutely identified that there are a whole lot of completely different the explanation why we eat. We do not simply eat as a result of we’re hungry, we eat as a result of it is a very social factor. And so if you’re a kind of people who find themselves in a whole lot of conditions the place there are social temptations to exit and eat socially, or we eat simply because the meals tastes good. I feel we will all relate to consuming ice cream out of a bathtub or ending off a bag of chips, not as a result of we are literally hungry, however as a result of it simply tastes good.
Michael Calore: I eat as a result of I am unhappy or offended.
Emily Mullin: Possibly that is a dialogue for one more podcast episode.
Kate Knibbs: I’ve a query, Emily, for you. Have you ever talked to any researchers who’ve been finding out the variations in outcomes between people who find themselves taking model title Ozempic or ZepBound, et cetera, and people who find themselves taking compounded meds? As a result of that is one thing that I have been looking for out, and I have not discovered anybody who’s finding out that but.
Emily Mullin: Yeah, I have not run throughout that.
Michael Calore: Is anyone doing any analysis in any respect about any of the compound medicine, like their security or the composition of them?
Kate Knibbs: Yeah, I have been looking for research which might be particularly wanting on the compounded variations, and it is actually exhausting. A number of the extra well-established telehealth clinics may have their very own lab work finished, and a few of them will share it, however impartial researchers, I do not know. If any of them are listening, I extremely encourage them to do it, as a result of … And once more, that is completely anecdotally, however of all the those who I do know on GLP-1 meds, the bulk are on compounded medicines.
